Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection.

• Main Authors: Rodrigo Assunção Holanda (Author), Julián Esteban Muñoz (Author), Lucas Santos Dias (Author), Leandro Buffoni Roque Silva (Author), Julliana Ribeiro Alves Santos (Author), Sthefany Pagliari (Author), Érica Leandro Marciano Vieira (Author), Tatiane Alves Paixão (Author), Carlos Pelleschi Taborda (Author), Daniel Assis Santos (Author), Oscar Bruña-Romero (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the im...