α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo

• मुख्य लेखकों: Yan Shi (लेखक), Candy Lee (लेखक), Peng Sang (लेखक), Zaid Amso (लेखक), David Huang (लेखक), Weixia Zhong (लेखक), Meng Gu (लेखक), Lulu Wei (लेखक), Vân T.B. Nguyen-Tran (लेखक), Jingyao Zhang (लेखक), Weijun Shen (लेखक), Jianfeng Cai (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Peptides are increasingly important resources for biological and therapeutic development, however, their intrinsic susceptibility to proteolytic degradation represents a big hurdle. As a natural agonist for GLP-1R, glucagon-like peptide 1 (GLP-1) is of significant clinical interest for the treatment...