α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo

• Main Authors: Yan Shi (Author), Candy Lee (Author), Peng Sang (Author), Zaid Amso (Author), David Huang (Author), Weixia Zhong (Author), Meng Gu (Author), Lulu Wei (Author), Vân T.B. Nguyen-Tran (Author), Jingyao Zhang (Author), Weijun Shen (Author), Jianfeng Cai (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptides are increasingly important resources for biological and therapeutic development, however, their intrinsic susceptibility to proteolytic degradation represents a big hurdle. As a natural agonist for GLP-1R, glucagon-like peptide 1 (GLP-1) is of significant clinical interest for the treatment...