Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel

• Main Authors: Chao Liu (Author), Wei Liu (Author), Yanhong Liu (Author), Hongxia Duan (Author), Liqing Chen (Author), Xintong Zhang (Author), Mingji Jin (Author), Minhu Cui (Author), Xiuquan Quan (Author), Libin Pan (Author), Jiachun Hu (Author), Zhonggao Gao (Author), Yan Wang (Author), Wei Huang (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extremely low bioavailability of oral paclitaxel (PTX) mainly due to the complicated gastrointestinal environment, the obstruction of intestinal mucus layer and epithelium barrier. Thus, it is of great significance to construct a coordinative delivery system which can overcome multiple intestina...