Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

• Main Authors: Yu-Mi Jeon (Author), Younghwi Kwon (Author), Shinrye Lee (Author), Seyeon Kim (Author), Myungjin Jo (Author), Seongsoo Lee (Author), Sang Ryong Kim (Author), Kiyoung Kim (Author), Hyung-Jun Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TAR DNA-binding protein 43 (TDP-43) is a member of an evolutionarily conserved family of heterogeneous nuclear ribonucleoproteins that modulate multiple steps in RNA metabolic processes. Cytoplasmic aggregation of TDP-43 in affected neurons is a pathological hallmark of many neurodegenerative diseas...