Human Umbilical Cord MSC Delivered-Soluble TRAIL Inhibits the Proliferation and Promotes Apoptosis of B-ALL Cell In Vitro and In Vivo

• Principais autores: Fangshan Chen (Autor), Xianmei Zhong (Autor), Qian Dai (Autor), Kuo Li (Autor), Wei Zhang (Autor), Jie Wang (Autor), Yueshui Zhao (Autor), Jing Shen (Autor), Zhangang Xiao (Autor), Hongyun Xing (Autor), Jing Li (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The TNF-related apoptosis-inducing ligand (TRAIL) could induce apoptosis of leukemic cells, while showed no cytotoxic effect on normal cells. One of the limitations for application of recombinant TRAIL (rhTRAIL) in leukemia treatment is that the serum half-life of this protein is short. Gene deliver...