Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

• Main Authors: Varun Kumar (Author), June Qin (Author), Yongfeng Jiang (Author), Richard G Duncan (Author), Benjamin Brigham (Author), Shannon Fishman (Author), Jayaprakash K Nair (Author), Akin Akinc (Author), Scott A Barros (Author), Pia V Kasperkovitz (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Formulation of short interfering RNA (siRNA) into multicomponent lipid nanoparticles (LNP) is an effective strategy for hepatic delivery and therapeutic gene silencing. This study systematically evaluated the effect of polyethylene glycol (PEG) density on LNP physicochemical properties, innate immun...