Microdialysis-directed Intra-tumor Pharmacokinetic Modeling of Methotrexate in Mice and Humans
Purpose. To develop a quantitative pharmacokinetic model to characterize the disposition of methotrexate (MTX) at tumor site in tumor-bearing mice and to predict MTX concentrations in the human tumor. Methods. The plasma profiles of MTX were obtained from normal mice, while microdialysis technique w...
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Frontiers Media S.A.,
2016-07-01T00:00:00Z.
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A1234.567 |
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