Microdialysis-directed Intra-tumor Pharmacokinetic Modeling of Methotrexate in Mice and Humans

Purpose. To develop a quantitative pharmacokinetic model to characterize the disposition of methotrexate (MTX) at tumor site in tumor-bearing mice and to predict MTX concentrations in the human tumor. Methods. The plasma profiles of MTX were obtained from normal mice, while microdialysis technique w...

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Main Authors: Helal H. Alsulimani (Author), Jonghan Kim (Author), Shabnam N. Sani (Author)
Format: Book
Published: Frontiers Media S.A., 2016-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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