A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations

• Main Authors: Carlos Garrido-Allepuz (Author), Endika Haro (Author), Domingo González-Lamuño (Author), María Luisa Martínez-Frías (Author), Federica Bertocchini (Author), Maria A. Ros (Author)
• Format: Book
• Published: The Company of Biologists, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirenomelia, also known as sirenomelia sequence, is a severe malformation of the lower body characterized by fusion of the legs and a variable combination of visceral abnormalities. The causes of this malformation remain unknown, although the discovery that it can have a genetic basis in mice repres...