ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

• Main Authors: Chun-Lin Lin (Author), Xi Tan (Author), Meizhen Chen (Author), Meena Kusi (Author), Chia-Nung Hung (Author), Chih-Wei Chou (Author), Ya-Ting Hsu (Author), Chiou-Miin Wang (Author), Nameer Kirma (Author), Chun-Liang Chen (Author), Ching-Hung Lin (Author), Kate I. Lathrop (Author), Richard Elledge (Author), Virginia G. Kaklamani (Author), Kohzoh Mitsuya (Author), Tim H.-M. Huang (Author)
• Format: Book
• Published: BMC, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chromothripsis is an event of genomic instability leading to complex chromosomal alterations in cancer. Frequent long-range chromatin interactions between transcription factors (TFs) and targets may promote extensive translocations and copy-number alterations in proximal contact...