Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection.

Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection.

<h4>Background</h4>The liver fluke Opisthorchis viverrini infects several million people in Southeast Asia. Adult flukes live in the bile ducts of humans, where they cause hepatobiliary pathology, including cholangiocarcinoma. Here, we investigated the potential of extracellular vesicles...

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Main Authors: Sujittra Chaiyadet (Author), Javier Sotillo (Author), Watchara Krueajampa (Author), Sophita Thongsen (Author), Paul J Brindley (Author), Banchob Sripa (Author), Alex Loukas (Author), Thewarach Laha (Author)
Format: Book
Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
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3rd Floor Main Library

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