Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

• Auteurs principaux: David E. Hines (Auteur), Shannon Bell (Auteur), Xiaoqing Chang (Auteur), Kamel Mansouri (Auteur), David Allen (Auteur), Nicole Kleinstreuer (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data gaps. While in vitro experiments have the advant...