Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

• Main Authors: David E. Hines (Author), Shannon Bell (Author), Xiaoqing Chang (Author), Kamel Mansouri (Author), David Allen (Author), Nicole Kleinstreuer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data gaps. While in vitro experiments have the advant...