Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

• Autores principales: David E. Hines (Autor), Shannon Bell (Autor), Xiaoqing Chang (Autor), Kamel Mansouri (Autor), David Allen (Autor), Nicole Kleinstreuer (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data gaps. While in vitro experiments have the advant...