Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of these compounds is presented against four human CA (hCA) isozymes, comprising hCA...

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Main Authors: Leonardo E. Riafrecha (Author), Macarena S. Le Pors (Author), Martín J. Lavecchia (Author), Silvia Bua (Author), Claudiu T. Supuran (Author), Pedro A. Colinas (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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