Oxygen-Loaded Nanodroplets Effectively Abrogate Hypoxia Dysregulating Effects on Secretion of MMP-9 and TIMP-1 by Human Monocytes

• Main Authors: Giulia Rossana Gulino (Author), Chiara Magnetto (Author), Amina Khadjavi (Author), Alice Panariti (Author), Ilaria Rivolta (Author), Marco Soster (Author), Monica Argenziano (Author), Roberta Cavalli (Author), Giuliana Giribaldi (Author), Caterina Guiot (Author), Mauro Prato (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monocytes play a key role in the inflammatory stage of the healing process. To allow monocyte migration to injured tissues, the balances between secreted matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) must be finely modulated. However, a reduction of blood supply and local oxygen tens...