Pharmacokinetic/Pharmacodynamic Based Breakpoints of Polymyxin B for Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Pathogens

• Main Authors: Xingchen Bian (Author), Xiaofen Liu (Author), Fupin Hu (Author), Meiqing Feng (Author), Yuancheng Chen (Author), Phillip J. Bergen (Author), Jian Li (Author), Xin Li (Author), Yan Guo (Author), Jing Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The latest PK/PD findings have demonstrated negligible efficacy of intravenous polymyxins against pulmonary infections. We investigated pharmacokinetic/pharmacodynamic (PK/PD)-based breakpoints of polymyxin B for bloodstream infections and the rationality of the recent withdrawal of polymyxin suscep...