Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

• Main Authors: Samar M. Abouelatta (Author), Ahmed A. Aboelwafa (Author), Omaima N. El-Gazayerly (Author)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5-7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble...