Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity

• Main Authors: C. Haberl (Author), L. Hültner (Author), A. Flügel (Author), M. Falk (Author), S. Geuenich (Author), W. Wilmanns (Author), C. Denzlinger (Author)
• Format: Book
• Published: Hindawi Limited, 1998-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostaglandin (PG) D2 , PGJ2 and Δ12 -PGJ2 are antiproliferative eicosanoids. We investigated the production of PGD2 by murine bone marrow-derived mast cells (BMMC) taking into consideration metabolism of PGD2 to PGD2 and Δ12-PGJ2. PG-metabolites were quantified by high performance liquid chromatogr...