RP-HPLC method development and validation for the quantification of Efonidipine hydrochloride in HME processed solid dispersions

• Main Authors: Ashish S. Rajput (Author), Durgesh K. Jha (Author), Sharda Gurram (Author), Devanshi S. Shah (Author), Purnima D. Amin (Author)
• Formato: Livro
• Publicado em: SpringerOpen, 2020-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Efonidipine hydrochloride (EFO) is a poorly water-soluble drug and, hence, has poor bioavailability. Solid dispersions (SDs) of EFO using Eudragit EPO were prepared using hot-melt extrusion (HME) for the first time. The current study aims at developing a simple RP-HPLC method to...