Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

• Main Authors: Hailong Yu (Author), Lilong Song (Author), Xiang Cao (Author), Wei Li (Author), Yuanyuan Zhao (Author), Jian Chen (Author), Jun Li (Author), Yingzhu Chen (Author), Wenkui Yu (Author), Yun Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cerebral ischaemia/reperfusion (CI/R) injury is a major challenge due to the lack of effective neuroprotective drugs. Hederagenin (HE) is the aglycone part of saponins extracted from Hedera helix Linné that has exhibited anti-apoptotic and anti-inflammatory effects; however, the role of HE in CI/R h...