The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa.

• Main Authors: Bruno Penas Seara Pitanga (Author), Ravena P Nascimento (Author), Victor Diogenes Amaral Silva (Author), Silvia Lima Costa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The metabolic interactions and signalling between neurons and glial cells are necessary for the development and maintenance of brain functions and structures and for neuroprotection, which includes protection from chemical attack. Astrocytes are essential for cerebral detoxification and present an e...