METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway

• المؤلفون الرئيسيون: Jinghua Wang (مؤلف), Shushan Yan (مؤلف), Hongying Lu (مؤلف), Shufeng Wang (مؤلف), Donghua Xu (مؤلف)
• التنسيق: كتاب
• منشور في: Hindawi Limited, 2019-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mec...