Structural and Affinity Analyses of G-Quadruplex DNA Aptamers for Camptothecin Derivatives

• Main Authors: Naoki Sugimoto (Author), Masayasu Kuwahara (Author), Yuuya Kasahara (Author), Shunsuke Kitadume (Author), Hiroaki Ozaki (Author), Yuri Imaizumi (Author), Hiroto Fujita (Author)
• Format: Book
• Published: MDPI AG, 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently selected DNA aptamers that bind to camptothecin (CPT) and CPT derivatives from a 70-mer oligodeoxyribonucleotide (ODN) library using the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method. The target-binding activity of the obtained 70-mer CPT-binding DNA aptamer, t...