Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice

• Main Authors: Shizhang Wei (Author), Tingting He (Author), Xu Zhao (Author), Manyi Jing (Author), Haotian Li (Author), Lisheng Chen (Author), Ruimao Zheng (Author), Yanling Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Farnesoid X receptor (FXR) is a key metabolic target of bile acids (BAs) and is also a target for drugs against several liver diseases. However, the contribution of FXR in the pathogenesis of cholestasis is still not fully understood. The purpose of this study is to provide a comprehensi...