Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution

• Main Authors: Yunliang Guo (Author), Xuyan Mao (Author), Jing Zhang (Author), Peng Sun (Author), Haiyang Wang (Author), Yue Zhang (Author), Yingjuan Ma (Author), Song Xu (Author), Renjun Lv (Author), Xueping Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lycopene is considered as a promising neuroprotector with multiple bioactivities, while its therapeutic use in neurological disorders is restricted due to low solubility, instability and limited bioavailability. Our work aimed to develop lycopene-loaded microemulsion (LME) and investigate its potent...