Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer

• Main Authors: Mitsuro Kanda (Author), Yuuya Kasahara (Author), Dai Shimizu (Author), Takashi Miwa (Author), Shinichi Umeda (Author), Koichi Sawaki (Author), Shunsuke Nakamura (Author), Yasuhiro Kodera (Author), Satoshi Obika (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...