Evaluation of P-glycoprotein expression in pain relevant tissues: understanding translation of efflux from preclinical species to human

• Main Authors: Renu Singh Dhanikula (Author), Cyrla Hoffert (Author), Rebecca Grant (Author), Denis Projean (Author), Rosemarie Panetta (Author), Dajan O'Donnell (Author), Marie Roumi (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Various efflux transporters, such as P-glycoprotein (P-gp) are now widely accepted to have profound influence on the disposition of substrates. Nevertheless, there is paucity of information about their expression and functionality in the pain relevant tissues (such as brain, spinal cord and dorsal r...