Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity

• Main Authors: Alba Clara Fernández-Rilo (Author), Nicola Forte (Author), Letizia Palomba (Author), Lea Tunisi (Author), Fabiana Piscitelli (Author), Roberta Imperatore (Author), Alfonso Di Costanzo (Author), Vincenzo Di Marzo (Author), Luigia Cristino (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the lateral hypothalamus. It exerts powerful control over brain function and physiology by regulating energy homeostasis and complex behaviors linked to arousal. Under conditions of chronic or acute brain leptin signalin...