Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury

• Main Authors: Jinpeng Zheng (Author), Caihong Lu (Author), Meiyan Yang (Author), Jiejie Sun (Author), Jinbang Zhang (Author), Yuanyuan Meng (Author), Yuli Wang (Author), Zhiping Li (Author), Yang Yang (Author), Wei Gong (Author), Chunsheng Gao (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As one of the most frequent complications of critical illness, acute lung injury (ALI) carries a high risk of clinical morbidity and mortality. Cepharanthine (CPA) has significant anti-inflammatory activity, however, due to poor water solubility, low bioavailability, and short half-life, it fails to...