Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy

• Main Authors: Jaakko Itkonen (Author), Leo Ghemtio (Author), Daniela Pellegrino (Author), Pia J. Jokela (née Heinonen) (Author), Henri Xhaard (Author), Marco G. Casteleijn (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offline measurements, which cannot directly assess pro...