Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse

• Päätekijät: Fiona K. Bangs (Tekijä), Paul Miller (Tekijä), Eric O'Neill (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2020-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths worldwide, but has a 5-year survival rate of only 7% primarily due to late diagnosis and ineffective therapies. To treat or even prevent PDAC, it is vital that we understand the initiating events that lead to...