A time-released osmotic pump fabricated by compression-coated method: Formulation screen, mechanism research and pharmacokinetic study

• Main Authors: Tiegang Xin (Author), Yang Zhao (Author), Hengpan Jing (Author), Wenji Zhang (Author), Yunyun Gao (Author), Xinggang Yang (Author), Xukai Qu (Author), Weisan Pan (Author)
• Format: Book
• Published: Elsevier, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this investigation, time-released monolithic osmotic pump (TMOP) tablets containing diltiazem hydrochloride (DIL) were prepared on the basis of osmotic pumping mechanism. The developed dosage forms were coated by Kollidon®SR-Polyethylene Glycol (PEG) mixtures via compression-coated technology ins...