Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation

• Main Authors: Zhilei Wang (Author), Guang Xu (Author), Hongbo Wang (Author), Xiaoyan Zhan (Author), Yuan Gao (Author), Nian Chen (Author), Ruisheng Li (Author), Xueai Song (Author), Yuming Guo (Author), Ruichuang Yang (Author), Ming Niu (Author), Jiabo Wang (Author), Youping Liu (Author), Xiaohe Xiao (Author), Zhaofang Bai (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idiosyncratic drug-induced liver injury (IDILI) is an infrequent but potentially serious disease that develops the main reason for post-marketing safety warnings and withdrawals of drugs. Epimedii Folium (EF), the widely used herbal medicine, has shown to cause idiosyncratic liver injury, but the un...