UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease

• Main Authors: He-Ping Lei (Author), Min Qin (Author), Li-Yun Cai (Author), Hong Wu (Author), Lan Tang (Author), Ju-E Liu (Author), Chun-Yu Deng (Author), Yi-Bin Liu (Author), Qian Zhu (Author), Han-Ping Li (Author), Wei Hu (Author), Min Yang (Author), Yi-Zhun Zhu (Author), Shi-Long Zhong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is widely accepted that genetic polymorphisms impact atorvastatin (ATV) metabolism, clinical efficacy, and adverse events. The objectives of this study were to identify novel genetic variants influencing ATV metabolism and outcomes in Chinese patients with coronary artery disease (CAD). A total o...