Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats

• Glavni autori: Šárka Vacková (Autor), Libor Kopkan (Autor), Soňa Kikerlová (Autor), Zuzana Husková (Autor), Janusz Sadowski (Autor), Elzbieta Kompanowska-Jezierska (Autor), Bruce D. Hammock (Autor), John D. Imig (Autor), Miloš Táborský (Autor), Vojtěch Melenovský (Autor), Luděk Červenka (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

An association between congestive heart failure (CHF) and chronic kidney disease (CKD) results in extremely poor patient survival rates. Previous studies have shown that increasing kidney epoxyeicosatrienoic acids (EETs) by blocking soluble epoxide hydrolase (sEH), an enzyme responsible for EETs deg...