Application of a novel microscopic technique for quantifying CA125 binding to circulating mononuclear cells in longitudinal specimens during treatment for ovarian cancer

• Main Authors: Kornél Lakatos (Author), Germán González (Author), Jawad Hoballah (Author), Jeff Brooker (Author), Sinyoung Jeong (Author), Conor Evans (Author), Petra Krauledat (Author), W. Peter Hansen (Author), Kevin M. Elias (Author), Manish Patankar (Author), Vilmos Fülöp (Author), Panagiotis A. Konstantinopoulos (Author), Daniel W. Cramer (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Measurement of serum CA125, an antigenic fragment of human mucin 16 (MUC16), is used to monitor the clinical progression of epithelial ovarian cancer (EOC). However, rather than simply a passive marker reflecting tumor burden, MUC16 may have a more active role by binding to immun...