Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages

• Main Authors: Finja C. Hansen (Author), Aftab Nadeem (Author), Kathryn L. Browning (Author), Mario Campana (Author), Artur Schmidtchen (Author), Mariena J.A. van der Plas (Author)
• Format: Book
• Published: Karger Publishers, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in monocytes and macrophages in a time- and temperature-d...