Activated O2•− and H2O2 Mediated Cell Survival in SU11274-Treated Non-Small-Cell Lung Cancer A549 Cells via c-Met-PI3K-Akt and c-Met-Grb2/SOS-Ras-p38 Pathways

The pharmacological activity of SU11274 is primarily due to its inhibition of hepotocyte growth factor receptor (c-Met) kinase overexpression. In this study, we demonstrated that the pathway involved in SU11274-induced autophagy was presumably through inhibition of c-Met and its down-stream pathways...

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Main Authors: Ying Liu (Author), Qi-Feng Shi (Author), Yuan-Chao Ye (Author), Shin-ichi Tashiro (Author), Satoshi Onodera (Author), Takashi Ikejima (Author)
Format: Book
Published: Elsevier, 2012-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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