Single‐cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle

• Main Authors: Ziye Xu (Author), Wenjing You (Author), Wentao Chen (Author), Yanbing Zhou (Author), Qiuyun Nong (Author), Teresa G. Valencak (Author), Yizhen Wang (Author), Tizhong Shan (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ageing is accompanied by sarcopenia and intramuscular fat (IMAT) infiltration. In skeletal muscle, fat infiltration is a common feature in several myopathies and is associated with muscular dysfunction and insulin resistance. However, the cellular origin and lipidomic and transcr...