Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

• Main Authors: Ling-shiang Chuang (Author), Joshua Morrison (Author), Nai-yun Hsu (Author), Philippe Ronel Labrias (Author), Shikha Nayar (Author), Ernie Chen (Author), Nicole Villaverde (Author), Jody Ann Facey (Author), Gilles Boschetti (Author), Mamta Giri (Author), Mireia Castillo-Martin (Author), Tin Htwe Thin (Author), Yashoda Sharma (Author), Jaime Chu (Author), Judy H. Cho (Author)
• Format: Book
• Published: The Company of Biologists, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in vivo systems are required to rapidly evaluate therape...