Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation

• Main Authors: Chang Yin (Author), Temesgen Fufa (Author), Gayathri Chandrasekar (Author), Madhu Aeluri (Author), Verina Zaky (Author), Shaimaa Abdelhady (Author), Antonio B. Rodríguez (Author), Johan Jakobsson (Author), Farzaneh Shahin Varnoosfaderani (Author), Jayashri Mahalingam (Author), Jianping Liu (Author), Olle Larsson (Author), Outi Hovatta (Author), Frank Gaunitz (Author), Anita Göndör (Author), Michael Andäng (Author), Satish S. Kitambi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach used in phenotype-based drug discovery (PDD) progra...