Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Abstract High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23-C45 disulfide form. HMGB1 also plays a key role as a mediator of acute and chronic inflammation in models of sterile injury. Although H...

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Main Authors: Sodam Kim (Author), Sun Young Kim (Author), John P. Pribis (Author), Michael Lotze (Author), Kevin P. Mollen (Author), Richard Shapiro (Author), Patricia Loughran (Author), Melanie J. Scott (Author), Timothy R. Billiar (Author)
Format: Book
Published: BMC, 2013-03-01T00:00:00Z.
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3rd Floor Main Library

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