Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

• Principais autores: Sodam Kim (Autor), Sun Young Kim (Autor), John P. Pribis (Autor), Michael Lotze (Autor), Kevin P. Mollen (Autor), Richard Shapiro (Autor), Patricia Loughran (Autor), Melanie J. Scott (Autor), Timothy R. Billiar (Autor)
• Formato: Livro
• Publicado em: BMC, 2013-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23-C45 disulfide form. HMGB1 also plays a key role as a mediator of acute and chronic inflammation in models of sterile injury. Although H...