Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening

IDH1 mutations occur in about 20-30% of gliomas and are a promising target for the treatment of cancer. In the present study, the performance of aIDH1R132H was verified via glide-docking-based virtual screening. On the basis of the two crystal structures (5TQH and 6B0Z) with the best discriminating...

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Principais autores: Yuwei Wang (Autor), Shuai Tang (Autor), Huanling Lai (Autor), Ruyi Jin (Autor), Xu Long (Autor), Na Li (Autor), Yuping Tang (Autor), Hui Guo (Autor), Xiaojun Yao (Autor), Elaine Lai-Han Leung (Autor)
Formato: Livro
Publicado em: Frontiers Media S.A., 2020-11-01T00:00:00Z.
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