Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening
IDH1 mutations occur in about 20-30% of gliomas and are a promising target for the treatment of cancer. In the present study, the performance of aIDH1R132H was verified via glide-docking-based virtual screening. On the basis of the two crystal structures (5TQH and 6B0Z) with the best discriminating...
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Frontiers Media S.A.,
2020-11-01T00:00:00Z.
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