The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm

• Main Authors: Sipin Zhu (Author), Ping Sun (Author), Samuel Bennett (Author), Oscar Charlesworth (Author), Renxiang Tan (Author), Xing Peng (Author), Qiang Gu (Author), Omar Kujan (Author), Jiake Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with characteristics of sesquiterpene lactones and exhibits the biological property of inhibiting DNA biosynthesis of cancer cells. I...