Sestrin1, 2, and 3 are dispensable for female fertility in mice

• Main Authors: Mengchen Wang (Author), Wenhui Chen (Author), Xinxin Zeng (Author), Taojun Wang (Author), Yingpu Sun (Author), Qingling Yang (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sestrins have been implicated in regulating aging in various organs through multiple pathways. However, their roles in ovarian aging remain unrevealed. Methods Female Sestrin1 −/− , Sestrin2 −/− , and Sestrin3 −/− mice were generated using the CRISPR-Cas9 system. Body weights, li...