NLRP3-MEDIATED RENAL LIPID ACCUMULATION OCCURS DURING EARLY DEVELOPMENT OF DIET-INDUCED CHRONIC KIDNEY DISEASE

• Main Authors: PJ Bakker (Author), LM Butter (Author), GWJ Teske (Author), L Kors (Author), FS Sutterwala (Author), J Aten (Author), S Florquin (Author), JC Leemans (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic syndrome (MetSyn) is an important risk factor for the development of chronic kidney disease (CKD). Metsyn-driven CKD is characterized by a state of chronic low-grade inflammation and the innate immune receptor Nlrp3 mediates inflammation. Therefore, we investigated the role of Nlrp3 on the...