Combination of Betulinic Acid Fragments and Carbonic Anhydrase Inhibitors-A New Drug Targeting Approach

• 主要な著者: Matthias Bache (著者), Niels V. Heise (著者), Andreas Thiel (著者), Anne Funtan (著者), Franziska Seifert (著者), Marina Petrenko (著者), Antje Güttler (著者), Sarah Brandt (著者), Thomas Mueller (著者), Dirk Vordermark (著者), Iris Thondorf (著者), René Csuk (著者), Reinhard Paschke (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human carbonic anhydrase IX (hCA IX) is a zinc(II)-dependent metalloenzyme that plays a critical role in the conversion of carbon dioxide and water to protons and bicarbonate. It is a membrane-bound protein with an extracellular catalytic center that is predominantly overexpressed in solid hypoxic t...