Requirement of the Ca2+ channel β2 subunit for sympathetic PKA phosphorylation

• Main Authors: Manabu Murakami (Author), Feng Xu (Author), Takayoshi Ohba (Author), Takeshi Kobayashi (Author), Yoshiro Inoue (Author), Agnieszka M. Murakami (Author), Ichiro Miyoshi (Author), Kyoichi Ono (Author), Noritsugu Tohse (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Facilitation of cardiac function in response to signals from the sympathetic nervous system is initiated by the phosphorylation of L-type voltage-dependent Ca2+ channels (VDCCs) by protein kinase A (PKA), which in turn is activated by β-adrenoceptors. Among the five subunits (α1, β, α2/δ, and γ) of...