NTRK gene aberrations in triple‐negative breast cancer: detection challenges using IHC, FISH, RT‐PCR, and NGS

• Main Authors: Federica Zito Marino (Author), Simona Buono (Author), Marco Montella (Author), Rosa Giannatiempo (Author), Francesco Messina (Author), Giovanni Casaretta (Author), Grazia Arpino (Author), Giulia Vita (Author), Francesco Fiorentino (Author), Luigi Insabato (Author), Alessandro Sgambato (Author), Michele Orditura (Author), Renato Franco (Author), Marina Accardo (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Triple‐negative breast cancer (TNBC) is usually an aggressive disease with a poor prognosis and limited treatment options. The neurotrophic tyrosine receptor kinase (NTRK) gene fusions are cancer type‐agnostic emerging biomarkers approved by the Food and Drug Administration (FDA), USA, for...