Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene

• Main Authors: Warnich Louise (Author), Kinnear Craig (Author), Venter Mauritz (Author), van der Merwe Lize (Author), Keyser Rowena J (Author), Carr Jonathan (Author), Bardien Soraya (Author)
• Format: Book
• Published: BMC, 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>DJ-1 forms part of the neuronal cellular defence mechanism against oxidative insults, due to its ability to undergo self-oxidation. Oxidative stress has been implicated in the pathogenesis of central nervous system damage in differen...