Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene

• Автори: Warnich Louise (Автор), Kinnear Craig (Автор), Venter Mauritz (Автор), van der Merwe Lize (Автор), Keyser Rowena J (Автор), Carr Jonathan (Автор), Bardien Soraya (Автор)
• Формат: Книга
• Опубліковано: BMC, 2009-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>DJ-1 forms part of the neuronal cellular defence mechanism against oxidative insults, due to its ability to undergo self-oxidation. Oxidative stress has been implicated in the pathogenesis of central nervous system damage in differen...