In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist

• Main Authors: Anne Lesage (Author), Christoph Gibson (Author), François Marceau (Author), Horst-Dieter Ambrosi (Author), Jörn Saupe (Author), Werner Katzer (Author), Brigitte Loenders (Author), Xavier Charest-Morin (Author), Jochen Knolle (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We here report the discovery and early characterization of Compound 3, a representative of a novel class of small molecule bradykinin (BK) B2 receptor antagonists, and its superior profile to the prior art B2 receptor antagonists Compound 1 and Compound 2. Compound 3, Compound 2, and Compound 1 are...