Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

• Main Authors: Minyuan Cao (Author), Dandan Yin (Author), Yun Qin (Author), Fei Liao (Author), Yali Su (Author), Xuyang Xia (Author), Ju Gao (Author), Yiping Zhu (Author), Wei Zhang (Author), Yang Shu (Author), Xiaoxi Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15. However, a minority of patients who suffered such adverse drug reaction have NUD...